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News for Healthier Living

Children's Hospital of Philadelphia and St. Jude Researchers Find Genetic Ancestry Influences How Gene Mutations Impact Cancer Prognosis in Patients With T-cell Acute Lymphoblastic Leukemia

Investigators at Children's Hospital of Philadelphia (CHOP), St. Jude Children's Research Hospital (St. Jude), Dana Farber Cancer Institute (DFCI), and the Children's Oncology Group (COG), unveiled for the first time that changes in certain genes affect an aggressive cancer, T-cell acute lymphoblastic leukemia (T-ALL), differently depending on genetic ancestry. The collaborative study, published recently in the journal Blood Cancer Discovery, further reinforces the critical role of personalized medicine in advancing the treatment of pediatric cancers such as T-ALL.

June 24, 2025


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