News for Healthier Living
Reshaping Tumor Neighborhoods to Give Treatments a Boost
 Cancer cells interact with their neighborhood -- which scientists term the tumor microenvironment -- in many ways, including obtaining extra resources needed to fuel their unchecked growth. Like a fishing trawler deploying its net, pancreatic ductal adenocarcinoma (PDAC) cells reform their cell surfaces to grab additional nutrients from the jelly-like substance between cells called the extracellular matrix.
This cellular scavenging process -- known as macropinocytosis -- affects the area surrounding the tumor, making the connective tissue stiffer and preventing immune cells from reaching the tumor.
Scientists at the NCI-Designated Cancer Center at Sanford Burnham Prebys published findings July 24, 2025, in Cancer Cell demonstrating that blocking macropinocytosis reshapes the tumor microenvironment to be less fibrous and to allow more access to immune cells. These changes made immunotherapy and chemotherapy more effective in treating PDAC tumors in mice.
July 24, 2025
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