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News for Healthier Living

Scientists Map How Aging Reshapes Cells Across the Entire Mammalian Body

About one-quarter of cell types across the body undergo significant shifts in their populations with age, including expansions of immune cells and declines in specialized kidney, muscle, and lung cells. Many aging-related changes are synchronized across organs, suggesting that systemic signals coordinate how the body ages rather than organs aging independently. About 40 percent of aging-associated cellular changes are sex-dependent, with females showing broader immune activation with age, potentially explaining higher rates of autoimmune disease in women.

February 26, 2026


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