News for Healthier Living
Biomimetic nanoparticle combines antibacterial and regenerative actions for periodontitis
A biomimetic nanoparticle that combines antibacterial, immunomodulatory, and regenerative actions could offer a more comprehensive strategy for periodontitis. Researchers developed neutrophil-macrophage hybrid membrane-coated minocycline-loaded gelatin nanoparticles (NMm@MINO) and evaluated whether the platform could control periodontal pathogens, reprogram macrophages toward a repair-associated phenotype, and support periodontal tissue repair. The nanoparticle was designed for protease-responsive drug release and tested for bactericidal activity in vitro, macrophage polarization, osteogenesis, osteoclastogenesis, fibroblast function, as well as its therapeutic effects in a ligature-induced rat model. The work supports a multi-target local therapeutic approach that addresses infection, inflammation, and tissue destruction together rather than focusing on bacterial control alone.
November 9, 2026
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- Biomimetic nanoparticle combines antibacterial and regenerative actions for periodontitis
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November 8 2026November 7 2026November 6 2026November 5 2026November 4 2026November 3 2026November 2 2026November 1 2026
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