Topic Overview
What are cold sores?
Cold sores, sometimes called
			 fever blisters, are groups of small blisters on the lip and around the mouth.
			 Often the first sign of a cold sore is a spot that tingles, burns, or itches. A blister usually forms within 24 hours. The skin around the blisters is often red, swollen, and sore. The blisters may
			 break open, leak a clear fluid, and then scab over after a few days. They
			 usually heal in several days to 2 weeks.
What causes cold sores?
Cold sores are caused by
			 the
			 herpes simplex virus (HSV). There are two types of
			 herpes simplex virus: HSV-1 and HSV-2. Both virus types can cause sores around the mouth (herpes labialis) and on the genitals (genital herpes). 
The herpes simplex virus
			 usually enters the body through a break in the skin around or inside the mouth.
			 It is usually spread when a person touches a cold sore or touches infected
			 fluid-such as from sharing eating utensils or razors, kissing an infected
			 person, or touching that person's saliva. A parent who has a cold sore often
			 spreads the infection to his or her child in this way. A person can spread the virus to someone else a few days  before the sore appears until the sore is completely healed. Cold sores can also be
			 spread to other areas of the body.
What are the symptoms?
 The first symptoms of cold
			 sores may include a spot that tingles, burns, or itches around your mouth and on your lips. You may also have a fever, a sore
			 throat, or swollen glands in your neck or other parts of the body. Small
			 children sometimes drool before cold sores appear. After the blisters appear,
			 the cold sores usually break open, leak a clear fluid, and then crust over and
			 disappear after several days to 2 weeks. For some people, cold sores can be
			 very painful.
Some people have the virus but don't get cold sores.
			 They have no symptoms.
How are cold sores diagnosed?
Your doctor can tell
			 if you have cold sores by asking you questions to find out whether you have
			 come into contact with the virus and by examining you. You probably won't need
			 any tests.
How are cold sores treated?
Cold sores will
			 usually start to heal on their own within a few days. But if they cause pain or
			 make you feel embarrassed, they can be treated. Treatment may include skin
			 creams, ointments, or sometimes pills. Treatment may get rid of the cold sores
			 only 1 to 2 days faster, but it can also help ease painful blisters or other
			 uncomfortable symptoms.
The herpes simplex virus that causes cold
			 sores can't be cured. After you get infected, the virus stays in your body for
			 the rest of your life. If you get cold sores often, treatment can reduce the
			 number of cold sores you get and how severe they are.
How can you prevent cold sores?
There are some
			 things you can do to keep from getting the herpes simplex virus.
- Avoid coming into contact with infected body fluids, such
				as kissing an infected person.
- Avoid sharing eating utensils,
				drinking cups, or other items that a person with a cold sore may have
				used.
 After you have been infected with the virus, there is no
			 sure way to prevent more cold sores. But there are some things you can do to
			 reduce your number of outbreaks and prevent spreading the virus.
- Avoid the things that trigger your cold sores, such as
				stress and colds or the flu.
- Always use lip balm and sunscreen on
				your face. Too much sunlight can cause cold sores to flare.
- Avoid
				sharing towels, razors, silverware, toothbrushes, or other objects that a
				person with a cold sore may have used.
- When you have a cold sore,
				make sure to wash your hands often, and try not to touch your sore. This can
				help keep you from spreading the virus to your eyes or genital area or to other
				people.
- Talk to your
				doctor if you get cold sores often. You may be able to take prescription pills
				to prevent cold sore outbreaks.
Frequently Asked Questions
| Learning about cold sores: |  | 
| Being diagnosed: |  | 
| Getting treatment: |  | 
| Living with cold sores: |  | 
Symptoms
Cold sores are
		  blisters on the lips and the edge of the mouth that are caused by an infection
		  with the
		  herpes simplex virus (HSV). Often the first sign of a cold sore is a spot that tingles, burns, or itches. A blister usually forms within 24 hours.
Cold sore
		  blisters usually break open, weep clear fluid, and then crust over and
		  disappear after a few days. 
Other symptoms may include:
- A sore mouth that makes eating, drinking, and
			 sleeping uncomfortable. Cold sores can be painful.
- A
			 fever.
- A sore throat.
- Swollen
			 lymph nodes in the neck.
- Drooling, in
			 small children.
You may not develop cold sores when you are first infected
		  with HSV. If cold sores do develop when you are first infected, they may be
		  more severe than in later outbreaks. During the first outbreak of cold sores,
		  the blisters may spread to any part of the mouth.
After you become
		  infected, HSV remains in your body and may cause cold sores to return
		  throughout your lifetime (recurrent cold sores).
Recurrent cold sores usually develop where
		  facial skin and the lip meet. About 6 to 48 hours before a cold sore is
		  visible, you may feel tingling, burning, itching, numbness, tenderness, or pain
		  in the affected area. This is called the prodromal stage.
Some
		  common triggers that cause cold sores to return include:
People who have weakened immune systems are more likely
		  than those with strong immune systems to have longer or more severe outbreaks
		  of cold sores. HSV infection may be life-threatening in certain people who have
		  weak immune systems.
Who is at greatest risk for developing cold sores?
Anyone who is exposed to the herpes simplex virus (HSV) is at risk for
			 developing cold sores. But many people have the virus and may never develop
			 cold sores.
People who have weakened immune systems are at an
			 increased risk for having more severe and longer-lasting outbreaks of cold
			 sores.
One form of HSV infection is seen most often in children 1
			 to 3 years old. This type of HSV infection (primary herpes stomatitis) can
			 cause a high fever and blisters throughout the mouth, which can interfere with
			 the ability to eat. It can be serious in children-they can get quite sick from
			 this illness, although they usually recover without any long-term problems. 
			 
Exams and Tests
Your doctor can diagnose
		  cold sores by asking questions to find out whether
		  you've been exposed to the
		  herpes simplex virus (HSV) and by examining you. No
		  further testing is usually needed.
There are two types of herpes
		  simplex virus: HSV-1 and HSV-2. Both virus types can cause lip and mouth sores
		  (herpes labialis) and
		  genital herpes if your skin comes into contact with
		  either type.
If it is not clear that you have cold sores,
		  herpes tests may be done. The doctor takes a sample of
		  fluid from a sore and has it tested. Having the sample taken is usually not
		  uncomfortable even if the sore is tender or painful. 
Treatment Overview
There is no cure for
		  cold sores, nor is there a cure for the
		  herpes simplex virus (HSV) that causes them. Most cold
		  sores will go away on their own. But medicines may slightly reduce the duration
		  of cold sores and sometimes prevent a future outbreak.
 Treatment
		  with medicines depends on whether you are having a first outbreak or a
		  recurrent outbreak or are trying to prevent future outbreaks.
When
		  treating a first outbreak of cold sores,
		  oral antiviral medicines may reduce pain and slightly improve healing
		  time.
For treatment of recurrent cold sores, the following
		  medicines may reduce the severity and duration of the outbreak:footnote 1
- Topical creams or ointments, which are
			 available with or without a prescription, can reduce pain, itching, and healing
			 time.
- Oral antiviral medicines, which are available by
			 prescription only, may be used when the first symptoms (such as burning or
			 itching) begin. These medicines have little effect after the sore
			 develops.
 Oral antivirals may also be taken daily to prevent
		  recurring cold sores, especially in people who have frequent and painful
		  outbreaks.
If you have a
		  weakened immune system and develop cold sores, you may
		  need medicines to control your symptoms or daily doses to
		  prevent outbreaks.
Other treatments
The first episode of cold sores
			 can be so painful that you may have trouble eating, drinking, and sleeping.
			 A child who has a fever and many mouth sores may need to be encouraged to drink
			 water and other fluids to prevent
			 dehydration.
Adults and older children
			 who have a painful first episode of cold sores may sometimes need a
			 prescription-strength medicated mouth rinse to reduce pain.
Complementary medicine
Several
			 complementary medicine treatments are available if you wish to try an
			 alternative way to ease your symptoms.
Vitamin C, lysine supplements, and lemon balm are  examples of complementary treatments that may provide some
relief during a cold sore outbreak. Vitamin C may be taken as an oral tablet, in a cream that can be put on the cold sore (topical cream), or as liquid vitamin C applied to the cold sore. Lysine supplements are taken as pills, and lemon balm is available in a topical cream.
			 Zinc oxide topical cream may reduce the duration of an outbreak.footnote 1
Home Treatment
Most
		  cold sores heal on their own. But you can manage your
		  symptoms at home by:
- Placing a cool, wet towel on the sores 3 times
			 a day for 20 minutes each time to help reduce redness and
			 swelling.
- Using a mouth rinse that has baking soda to
			 soothe a sore mouth.
- Avoiding foods that contain acid (such as
			 citrus fruits and tomatoes).
- Using nonprescription ointments that
			 can relieve pain or help heal the cold sore.  - Some products such as Abreva and
			 Zilactin can speed the healing of cold sores or prevent them if
			 applied early enough.
- Other products such as Orajel and Anbesol can numb sore
			 areas in the mouth or on the lips.
- Children age 2 and older can be treated with Zilactin-L Liquid, Orajel Baby, and Anbesol.  Abreva is for people age 12 and older, so talk to your doctor before using it for a younger child. And if your child is younger than 2, talk to your doctor before using any of these medicines.
 
Ask your doctor if you can take ibuprofen (such as Advil or Motrin) or
			 acetaminophen (such as Tylenol) to reduce pain. Do not give aspirin to anyone younger than 20 because of its link to
			 Reye syndrome, a serious but rare problem. Be safe with medicines. Read and follow all instructions on the label
You can reduce the frequency of cold sore outbreaks by
		  taking the following steps:
- Avoid prolonged exposure of your lips to
			 sunlight.  Protect your face from the sun. Using lip balm that contains sunscreen may help reduce outbreaks of cold sores.
- Avoid intimate
			 contact (such as kissing) with people who have cold sores or
			 genital herpes.
- Avoid foods that seem to cause your cold
			 sores to recur. Some people find that they have fewer outbreaks if they don't eat nuts, chocolate, or gelatin.
- Avoid sharing towels, razors, silverware,
			 toothbrushes, or other objects that a person with a cold sore may have
			 used.
These measures may help prevent the spread of cold sores in
		  children:
- Encourage frequent hand-washing.
- Do
			 not let children share toys that other children put in their
			 mouths.
- Clean toys occasionally with a disinfectant.
- If
			 children have open or weeping cold sore blisters, keep them home until the
			 blisters begin to scab over.
- Do not let children kiss each other
			 while they have cold sores or uncontrollable drooling.
- Use disposable gloves
			 or a cotton swab to apply medicated ointment to a child's cold sores.
Other Places To Get Help
Organizations
American Academy of Dermatology
www.aad.org
American Sexual Health Association: Herpes Resource Center
www.ashastd.org/std-sti/Herpes.html
References
Citations
- Worrall G (2009). Herpes labialis, search date February 2009. Online version of BMJ Clinical Evidence: http://www.clinicalevidence.com.
Other Works Consulted
-  Wolff K, et al. (2013). Herpes simplex virus disease. In Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology, 7th ed., pp. 660-667. New York: McGraw-Hill.
- Habif TP, et al. (2011). Herpes simplex section of Viral infections. In Skin Disease: Diagnosis and Treatment, 3rd ed., pp. 224-229. Edinburgh: Saunders.
- Sterling JC (2010). Herpes labialis. In MG Lebwohl et al., eds., Treatment of Skin Disease: Comprehensive Therapeutic Strategies, pp. 303-305. Edinburgh: Saunders Elsevier
Credits
ByHealthwise Staff
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Adam Husney, MD - Family Medicine
Specialist Medical ReviewerKathleen Romito, MD - Family Medicine
Current as ofMarch 20, 2017